Myeloma induced osteolysis and nephromegaly
نویسندگان
چکیده
منابع مشابه
Activin A promotes multiple myeloma-induced osteolysis and is a promising target for myeloma bone disease.
Understanding the pathogenesis of cancer-related bone disease is crucial to the discovery of new therapies. Here we identify activin A, a TGF-beta family member, as a therapeutically amenable target exploited by multiple myeloma (MM) to alter its microenvironmental niche favoring osteolysis. Increased bone marrow plasma activin A levels were found in MM patients with osteolytic disease. MM cell...
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College of Life Sciences, Nankai University, Tianjin 300071, China Department of Biochemistry, Rush University, Chicago, IL 60612 State Key Laboratory of Experimental Hematology, Institute of Hematology & Blood Diseases, Chinese Academy of Medical Sciences, Tianjin 300020, China Department of Surgery, University of Pittsburgh, Pittsburgh, PA 15240 Hematology/Oncology, Indiana University School ...
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A patient is described with light chain myeloma and amyloidosis in whom 2 unusual complications occurred, diffuse osteolytic lesions and tetany. These observations extend the previously recognized clinical spectrum of this disorder.
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INTRODUCTION Postmenopausal osteoporosis may modulate bone response to wear debris. In this article, we evaluate the influence of oestrogen deficiency on experimental particle-induced osteolysis. METHODS Polyethylene (PE) particles were implanted onto the calvaria of normal controls, sham-ovariectomized (OVX), OVX mice and OVX mice supplemented with oestrogen (OVX+E). After 14 days, seven sku...
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TNF-alpha is the dominant cytokine in inflammatory osteolysis. Using mice whose BM stromal cells and osteoclast precursors are chimeric for the presence of TNF receptors, we found that both cell types mediated the cytokine's osteoclastogenic properties. The greater contribution was made, however, by stromal cells that express the osteoclastogenic cytokine M-CSF. TNF-alpha stimulated M-CSF gene ...
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ژورنال
عنوان ژورنال: Case Reports
سال: 2009
ISSN: 1757-790X
DOI: 10.1136/bcr.07.2008.0510